منابع مشابه
Prevention of antibody-mediated elimination of ligand-targeted liposomes by using poly(ethylene glycol)-modified lipids.
One of the major obstacles in the development of ligand-targeted liposomes is poor liposome circulation longevity as a result of antibody-mediated elimination of these highly immunogenic carriers. Because studies from our laboratory suggest that it is not possible to reduce the immunogenicity of ligand-conjugated liposomes by using surface-grafted poly(ethylene glycol) (PEG), we investigated th...
متن کاملSurfactants in Liposomes for Targeted Drug Delivery
Liposome is colloidal, vesicular structures capable of targeting to specific sites. Evans blue dye (hydrophilic dye) were formulated in liposomes using phosphatidyl choline, cholesterol and those liposomes were modified using surfactants surfactants span 20 , span 40 , span 80 or tween 80 at various molar ratio and optimized for its stable vesicular formation. The particle size and FTIR analysi...
متن کاملMannosylated liposomes for targeted gene delivery
BACKGROUND Liposomes can be modified with different ligands to control their biological properties, such as longevity, targeting ability, and intracellular penetration, in a desired fashion. The aim of this study was to modify liposomes with a novel mannosylated polyethylene glycol-phosphatidylethanolamine (M-PEG-PE) ligand to achieve active targeted gene delivery. METHODS Rat Kupffer cells w...
متن کاملTargeted Cationic Liposomes , Technologies , and Developments
Anas El-Aneed is a doctoral student in biochemistry at the School of Pharmacy at Memorial University of Newfoundland, 300 Prince Philip Dr., St. John’s, NL, A1B 3V6 Canada, tel. 709.737.4331, fax 709.777.7044, [email protected]. ationic liposomes are widely used to transfer genetic materials into specific cells. A good liposomal formulation for gene therapy should encapsulate and protect the nu...
متن کاملDocetaxel delivery using folate-targeted liposomes: in vitro and in vivo studies
Objective(s): Folate-targeted liposomes have been well considered in folate receptor (FR) overexpressing cells including MCF-7 and 4T1 cells in vitro and in vivo. The objective of this study is to design an optimum folate targeted liposomal formulations which show the best liposome cell uptake to tumor cells.Material and Methods: In this study, we prepared and characterized different targ...
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ژورنال
عنوان ژورنال: Health and Primary Care
سال: 2020
ISSN: 2515-107X
DOI: 10.15761/hpc.1000188